31 July 2009

New Edge videos explore the staggering potential of genetics

What is life? Can we create it? Customize it? Edge has just published over six hours of video from their new Master Class on the future of biology, which attempts to answer those and other provocative questions. Featuring geneticists George Church and Craig Venter, the set is a a surprising, challenging look at what science has in store for our world, from the minds of two of the field's most fascinating pioneers.

Summarizes attendee George Dyson,

In this future -- whose underpinnings, as Drs. Church and Venter demonstrated, are here already -- life as we know it is transformed [...] by discovering how to read genetic sequences directly into computers, where the code can be replicated exactly, manipulated freely, and translated back into living organisms by writing the other way.

Visit the Edge Master Class and start watching now >>

You'll notice several familiar faces among the class' pupils, including TED speakers Larry Brilliant, Larry Page, Nathan Wolfe, Nathan Myhrvold and Stewart Brand.

Photo: George Church (left); Craig Venter (right). Credit: Edge.org

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03 May 2009

The week in comments

This was an especially lively week on the TED commenting front, as our community tackled debates on swine flu, race and politics, and globalization. These amazing discussions can get a little heated -- so we appreciate that there always seems to be a voice of reason that emerges from the group to soothe frazzled nerves and streamline the discussion with a nod to both sides.

This one's for the peace-makers:

On Alex Tabarrok's interview with the TEDBlog:
TED talks are supposed to create debate, not end them.. Seems this one was a success then? -- Oli

On Nathan Wolfe's interview with the TEDBlog:
Bird flu is essentially a veterinary problem. Swine Flu is essentially a human health problem, and so is alarmism and fear. But not information and prevention, those are on our side and also on our side is the augmentation of average temperatures in the coming months and...wash your hands! -- Manel via facebook

On Laurie Garrett's TEDTalk: What can we learn from the 1918 flu pandemic?:
I thought this was particularly insightful given the evolution of the H1n1 virus in Mexico this past week. I heard people are reusing masks even those found in the trash cans. They wash and re-sell them, this is one case where ignorance kills and spreads a flu -- Juan via facebook

On Nate Silver's interview with the TEDBlog:
But yes, he is not pinheaded nor racist. He _is_ a nerdy dude who is big on analyzing and finding relationships within information... public speaking is not his forte. -- Toby via facebook

And, sometimes, the community glue is the speaker themselves:

On Brian Cox's TEDTalk: What went wrong (and what's next) at the Large Hadron Collider:
If the Higgs bosun particle (God particle), when found, is as congenial as Brian Cox, I think we can all agree to presuppose why the elementary particles cohere. -- Adrian

Thanks for keeping the debate alive.

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28 April 2009

Q&A on swine flu with virus hunter Nathan Wolfe: "We've created a perfect storm for viruses"

Swine flu has made this a busy week for virus hunter Nathan Wolfe, who spoke at TED2009 about preventing the next pandemic. His groundbreaking Global Viral Forecasting Initiative (supported by grants from Google.org, the Skoll Foundation and others) monitors people in close contact with animals (such as subsistence hunters in central Africa) to catch new diseases before they spread. We caught up with Wolfe yesterday by phone, before his appearance on CNN with Anderson Cooper (who plays a cameo role in Wolfe's TEDTalk), and asked him about this latest outbreak.

SARS, avian flu, swine flu ... what's going on here? Why are we suddenly seeing so many more outbreaks of viruses from animals?

Viruses have always passed from humans to animals. In fact, the vast majority of human diseases have animal origins. But the human population is different from what it once was. For most of our history, we lived in geographically disparate populations. So viruses could enter from animals into humans, spread locally and go extinct. But the human population has gone through a connectivity explosion. All humans on the planet are now connected to each other spatially and temporally in a way that's unprecedented in the history of vertebrate biology. Humans -- as well as our domestic animals and wild animals we trade -- move around the planet at biological warp speed. This provides new opportunities for viruses that would have gone extinct locally to have the population density fuel they need to establish themselves and spread globally.

We've created a "perfect storm" for viruses. And we'll continue to see -- as we have in the past few years -- a whole range of new animal diseases as outbreaks in human populations. But we have to stop being surprised by them. Right now, global public health is like cardiology in the '50s -- just waiting for the heart attack, without understanding why they occur or the many ways to monitor for them, detect them early and ultimately prevent them. Swine flu is not an anomaly. We know that swine flu -- like the vast majority of new outbreaks -- comes from animals. We should be monitoring those animals and the humans that come into contact with them, so we can catch these viruses early, before they infect major cities and spread throughout the world.

Can we stop swine flu? Or is it too late?
If you catch one of these outbreaks early on, there may be the potential to do what we call containment, where you limit the outbreak to a particular site. But the reality is: By the time swine flu got on the radar screen of global public health, it had already spread. It was already in the States, it was in Mexico, it was in New Zealand. By the time it reaches that point, you've lost the ability to contain it. There are ways to decrease the spread of the pandemic, but by that point, it can't be contained. (Editor's note: See Larry Brilliant's 2006 TEDTalk for more on the importance of early containment.)

The more fundamental question is: How do we prevent these pandemics from occurring? There are commonalities among all the pandemics that occur, and we can learn from them. One commonality is that they all come from animals. And the other commonality is that we wait too long.

At the Global Viral Forecasting Initiative, our approach is to take it a step back. If we can contain and monitor animal viruses at an earlier stage -- when they're first entering human populations, preferably before they've had a chance to become human-adapted, certainly before they've had a chance to spread -- we can head off pandemics altogether.

Swine flu may or may not end up being an important human pandemic. But it's a perfect illustration of the need for a paradigm shift in the way we approach global disease control.

In your TEDTalk, you lay out plans for monitoring humans who have close contact with animals in African jungles and Asian "wet markets." Should you be monitoring pig farms as well?

Absolutely. What we do is all of the above. We monitor people with contact with wild animals as well as domestic animals. Chickens, ducks, pigs, monkeys ... wherever people have contact with animals, that's where we want to be, so we can catch potential pandemics at the moment that they're born.

The good news is: For a variety of reasons, the percentage of the human population that's in direct contact with animals is decreasing. So that gives us the potential to put a substantive percentage of that population into regular monitoring. Maybe we won't catch everything, but we can create a much more substantive safety net for capturing these things before they go international or global.

READ MORE: Nathan Wolfe talks about why swine flu victims are dying in Mexico but not yet in the US; how swine flu is a "cosmopolitan virus"; and more ...

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31 March 2009

TED and National Geographic: Shared mission, shared planet, shared stage

National Geographic shares stories that inspire people to care for our world, and TED leverages the power of ideas to change the world. It could be said that we share some common ground.

Unsurprisingly, almost half of the National Geographic Explorers, as well as a few members of their staff, have given TEDTalks. Below the jump is a list of links to all the talks that bring TED and National Geographic together.

Here's National Geographic Explorer and TED Prize 2009 winner Sylvia Earle:

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27 March 2009

An immune system for the planet: Exclusive interview with Nathan Wolfe

Using genetic sequencing, needle-in-a-haystack research, and dogged persistence (crucial to getting spoilage-susceptible samples through the jungle and to the lab), Nathan Wolfe has proven what was science-fiction conjecture only a few decades ago -- not only do viruses jump from animals to humans, but they do so all the time. Along the way Wolfe has discovered several new viruses, and is poised to discover many more.

The TED Blog interviewed Wolfe over the phone shortly before his appearance at the Skoll World Forum on Social Entrepreneurship. He discusses the fact that vaccines often act as a crutch after the failure of preventative measures against disease, the need for a "global immune system" implemented through communication technologies such as SMS, and occasions when it's professionally acceptable -- and socially crucial -- to eat rodents. Here's a snippet:

I think about the secondary effects of diseases like AIDS that cause a population's immune system to be suppressed, as a whole. I think of this as a tear in the planet's meta-immune system. This tear increases the possibility that a new virus will enter. With immunosuppressed hunters, a virus that normally couldn't survive or adapt to human populations might get a few extra generations and be permitted to adapt to these individuals and humanity.

Read the full interview, after the jump >>

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26 March 2009

Hunting for the next AIDS: Nathan Wolfe on TED.com

Virus hunter Nathan Wolfe is outwitting the next pandemic by staying two steps ahead: discovering new, deadly viruses where they first emerge -- passing from animals to humans among poor subsistence hunters in Africa -- before they claim millions of lives. (Recorded at TED2009, February 2009, in Long Beach, California. Duration: 12:20.)

Watch Nathan Wolfe's talk from TED2009 on TED.com, where you can download this TEDTalk, rate it, comment on it and find other talks and performances from our archive of 400+ TEDTalks -- including more talks about medicine without borders.

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